AUTHOR=Papageorgiou Anastasios , Sofiou Fragkiski-Ioanna , Philippou Anastassios , Gkrampovari Maria , Agiannitopoulos Konstantinos , Traikov Lubomir 
  
TITLE=Pilot analysis of protein profile alterations in plasma and aortic tissue of spontaneously hypertensive rats
  
JOURNAL=Acta Biochimica Polonica
  
VOLUME=Volume 73 - 2026
  
YEAR=2026
  
URL=https://www.frontierspartnerships.org/journals/acta-biochimica-polonica/articles/10.3389/abp.2026.16571
  
DOI=10.3389/abp.2026.16571
  
ISSN=1734-154X
  
ABSTRACT=The role of proteins in cellular activity has received close attention. Proteome analysis can detect early enough changes in the cell before the appearance of pathological changes. Due to the increasing number of cardiovascular complications, more specifically hypertension in modern life, this experimental pilot study tries to detect early changes in the protein profile in cases with arterial hypertension. In this pilot study, animal models were used, specifically control rats and spontaneously hypertensive rats (SHRs), which are widely used as translational models relevant to human cardiovascular physiology. Using gel electrophoresis (GE) method, we analysed proteomic signature of blood plasma and aorta tissue samples of the animal models.