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<article article-type="letter" dtd-version="2.3" xml:lang="EN" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Br J Biomed Sci</journal-id>
<journal-title>British Journal of Biomedical Science</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Br J Biomed Sci</abbrev-journal-title>
<issn pub-type="epub">2474-0896</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">14125</article-id>
<article-id pub-id-type="doi">10.3389/bjbs.2024.14125</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Health Archive</subject>
<subj-group>
<subject>Letter to the Editor</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>A Letter to the Editor: The Peer Review Process: Past, Present, and Future</article-title>
<alt-title alt-title-type="left-running-head">Khalifa</alt-title>
<alt-title alt-title-type="right-running-head">Peer Review Process Obstacles</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Khalifa</surname>
<given-names>Ahmed A.</given-names>
</name>
<xref ref-type="corresp" rid="c001">&#x2a;</xref>
<xref ref-type="fn" rid="fn1">
<sup>&#x2020;</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1817676/overview"/>
</contrib>
</contrib-group>
<aff>
<institution>Orthopaedic Department</institution>, <institution>Qena Faculty of Medicine and University Hospital</institution>, <institution>South Valley University</institution>, <addr-line>Qena</addr-line>, <country>Egypt</country>
</aff>
<author-notes>
<corresp id="c001">&#x2a;Correspondence: Ahmed A. Khalifa, <email>ahmed_adel0391@med.svu.edu.eg</email>, <email>khalifaahmed8486@yahoo.com</email>
</corresp>
<fn fn-type="other" id="fn1">
<label>
<sup>&#x2020;</sup>
</label>
<p>ORCID: Ahmed A. Khalifa, <ext-link ext-link-type="uri" xlink:href="http://orcid.org/0000-0002-0710-6487">orcid.org/0000-0002-0710-6487</ext-link>
</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>15</day>
<month>01</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>81</volume>
<elocation-id>14125</elocation-id>
<history>
<date date-type="received">
<day>26</day>
<month>11</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>31</day>
<month>12</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2025 Khalifa.</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Khalifa</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<kwd-group>
<kwd>research integrity</kwd>
<kwd>peer review</kwd>
<kwd>double blind</kwd>
<kwd>preprints</kwd>
<kwd>anonymous peer review</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<sec id="s1">
<title>Introduction</title>
<p>Dear editor, I have read the interesting article &#x201c;The Peer Review Process: Past, Present, and Future&#x201d; by Drozdz and Ladomery [<xref ref-type="bibr" rid="B1">1</xref>]. The authors elegantly describe the various approaches to peer review during scientific article evaluation and how each approach has its advantages and disadvantages.</p>
<p>The authors alluded to &#x201c;Double anonymous peer review,&#x201d; which is characterized by &#x201c;Neither party knows the identity of the other at any point during the process [<xref ref-type="bibr" rid="B2">2</xref>],&#x201d; as they referred to in their detailed review. Furthermore, they mentioned that one of the claimed benefits of this approach for a peer-review process is the reduction of possible biases originating from revealing the author&#x2019;s identity (gender, affiliation, and other possible identities that could induce unconscious bias) [<xref ref-type="bibr" rid="B2">2</xref>&#x2013;<xref ref-type="bibr" rid="B5">5</xref>].</p>
</sec>
<sec id="s2">
<title>What Is Missing in the &#x201c;Problems Associated With the Peer Review Process&#x201d; Section?</title>
<p>I was expecting the authors to discuss how &#x201c;Double anonymous peer review&#x201d; is breached by the authors (intentionally or unintentionally) under the section Problems Associated With the Peer Review Process, which might include one or more of the following:<list list-type="simple">
<list-item>
<p>1-&#x2009;Some journals oblige authors submitting randomized controlled trials (RCTs) to provide the identity of their trial registration in one of the online registration databases (such as <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/">https://clinicaltrials.gov/</ext-link>). If the registration ID was presented in the &#x201c;anonymized&#x201d; or &#x201c;blinded&#x201d; version of the manuscript, the reviewers could quickly identify the authors and their details by checking the registration details.</p>
</list-item>
<list-item>
<p>2-&#x2009;Another example of breaching Double anonymous peer review occurs when authors submit a systematic review article. Reviewers could easily identify the authors if they reported details of their systematic review protocol registration (in one of the databases such as PROSPERO, <ext-link ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero/">https://www.crd.york.ac.uk/prospero/</ext-link>).</p>
</list-item>
<list-item>
<p>3-&#x2009;Some journals offer the authors the option to post their submitted, pre-peer-review manuscript to one of the preprint online repositories (such as Research Square <ext-link ext-link-type="uri" xlink:href="https://www.researchsquare.com/">https://www.researchsquare.com/</ext-link>), where the details of the authors are revealed [<xref ref-type="bibr" rid="B6">6</xref>].</p>
</list-item>
<list-item>
<p>4-&#x2009;If the authors state the setting of their study or define the details of their ethical committee board, their nationality or affiliation (not necessarily the exact authors&#x2019; identity) could be exposed.</p>
</list-item>
<list-item>
<p>5-&#x2009;Lastly, if the authors alluded to some of their previous work, such as mentioning &#x201c;in a previous study, we reported&#x2026;.&#x201d; The reviewer could identify the authors or at least the study group by following their previously published article.</p>
</list-item>
</list>
</p>
</sec>
<sec sec-type="discussion" id="s3">
<title>Discussion</title>
<p>In a scientific community overwhelmed by fraud, falsification, and questioned integrity, all possible actions must be followed to eliminate or minimize these dangers; one way to approach a fair and intact scientific research community is a sound peer review process, as explained in detail by Drozdz and Ladomery [<xref ref-type="bibr" rid="B1">1</xref>].</p>
<p>Although many peer review practices were suggested, and each has pros and cons, many scientists believe that the double anonymous peer review approach offers less bias as the reviewers do not know the author&#x2019;s identity and <italic>vice versa</italic>. However, if it is breached by one of the abovementioned possibilities, it loses its main advantage.</p>
<p>Cooperation between the authors, the editorial team, and the reviewers is needed to ensure the integrity of the double-anonymous peer review process as follows:<list list-type="simple">
<list-item>
<p>1-&#x2009;The authors must follow the journal instructions and remove any information that could lead to their identification. They must also report if their manuscript was deposited in one of the preprint servers.</p>
</list-item>
<list-item>
<p>2-&#x2009;The editorial team should review the manuscript thoroughly to ensure an anonymous presentation. Further, some journals stated they would not accept submissions in which the original manuscript was published as a preprint [<xref ref-type="bibr" rid="B7">7</xref>].</p>
</list-item>
<list-item>
<p>3-&#x2009;The reviewers should decline to review manuscripts if the authors&#x2019; identity could be revealed. However, if they decide to complete their review process, they need to clearly state that they detected a breach regarding the blinding of the manuscript they had reviewed. In this situation, it is up to the editor to include their report or not.</p>
</list-item>
</list>
</p>
<p>In conclusion, the double-anonymous peer review approach is vulnerable to breaches, which could be intentional or unintentional. To improve the efficiency of such a process, cooperation between the authors, editorial team members, and potential reviewers is needed to detect and inform about breaches of the manuscript&#x2019;s anonymized presentation.</p>
</sec>
</body>
<back>
<sec sec-type="data-availability" id="s4">
<title>Data Availability Statement</title>
<p>The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec sec-type="author-contributions" id="s5">
<title>Author Contributions</title>
<p>The author confirms being the sole contributor of this work and has approved it for publication.</p>
</sec>
<sec sec-type="funding-information" id="s6">
<title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<sec sec-type="COI-statement" id="s7">
<title>Conflict of Interest</title>
<p>The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="ai-statement" id="s8">
<title>Generative AI Statement</title>
<p>The author(s) declare that no Generative AI was used in the creation of this manuscript.</p>
</sec>
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