AUTHOR=Millar Beverley C. , Peters Callum , Moore John E. TITLE=An Analysis of the Readability of Public-Facing Information Relating to Prevention of Infectious Diseases by Vaccination JOURNAL=British Journal of Biomedical Science VOLUME=Volume 82 - 2025 YEAR=2025 URL=https://www.frontierspartnerships.org/journals/british-journal-of-biomedical-science/articles/10.3389/bjbs.2025.15435 DOI=10.3389/bjbs.2025.15435 ISSN=2474-0896 ABSTRACT=PurposeThe readability of public-facing vaccine-related information is an important aspect of health literacy particularly regarding vaccine uptake. The aims of this study were to analyse the readability of such written literature and to provide recommendations, for improvement.MethodsReadability of vaccine-related information (ntotal = 240) from publicly available sources (n = 20 per category), including PubMed Abstracts, Expert Review of Vaccines (ERV) and Cochrane Reviews (CR), paired plain language and scientific abstracts, public health materials, clinical trial summaries and vaccine patient information leaflets, were assessed using the Flesch Reading Ease (FRE), Flesch-Kincaid Grade Level (FKGL), SMOG and Gunning Fog readability metrics using the readability software tool readable.com.ResultsVaccine-related information for all sources had poor readability across all readability metrics with 90.8% and 94.6% not reaching the target FKGL (≤8) (mean 12 ± 3.2 sd) and FRE (≥60) (mean 34 ± 17 sd). Plain language summaries had improved readability, but did not reach reference targets. Scientific abstract and plain language scores for the CR were FRE (mean 25 ± 7.2 sd; median 25) versus (mean 37 ± 8.6 sd; median 36) p < 0.0001), respectively and for ERV FRE the scientific abstract (mean 18 ± 11 sd; median 17) versus the plain language score (mean 26 ± 11 sd; median 28) p = 0.002), respectively, indicating an improvement in readability scores for plain language summaries but again not reaching reference targets.ConclusionThe readability of public-facing vaccination materials is currently not optimum. The readability can be improved through the employment of readability calculators and ensuring, where possible, the use of mono-syllable words and less than fourteen words per sentence. The preparation of public-facing materials with improved readability scores will help aid in the promotion of health literacy and in turn promote vaccination uptake.