AUTHOR=Johannesson Liza , Fischbach Connor , Walker Olivia , Testa Giuliano 

TITLE=Past, Present, and Future: A Review of Uterus Transplant

JOURNAL=Transplant International

VOLUME=Volume 38 - 2025

YEAR=2025

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2025.15325

DOI=10.3389/ti.2025.15325

ISSN=1432-2277

ABSTRACT=Since the first live birth in 2014 after uterus transplantation, the procedure has become a viable fertility treatment worldwide for the 1 in 500 women affected by absolute uterine factor infertility. In this review, we provide insight on Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) and the other conditions that lead to the development of AUFI. Additionally, we provide a comprehensive overview of the evolution of uterus transplantation from the first sporadic cases to the current clinical status of the procedure, and detail multiple aspects that go into a successful UTx. Furthermore, we review some of the more recent developments in this rapidly expanding field and evaluate the prospective direction of UTx.