AUTHOR=Prosperi Edoardo , Prosperi Enrico , Serenari Matteo , Bonatti Chiara , Fallani Guido , Stocco Alberto , Radi Giorgia , Mirici Cappa Federica , Laici Cristiana , Siniscalchi Antonio , Morelli Maria Cristina , Ravaioli Matteo , Cescon Matteo 

TITLE=Evaluating Post-Transplant Outcomes in Elderly Liver Recipients Over 70: A Propensity-Score Matching Analysis

JOURNAL=Transplant International

VOLUME=Volume 38 - 2025

YEAR=2025

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2025.15429

DOI=10.3389/ti.2025.15429

ISSN=1432-2277

ABSTRACT=The rising prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Hepatocellular Carcinoma in the elderly population has increased the demand for liver transplantation (LT) in patients over 70 years. Advanced age, however, is still considered an independent risk factor. This study aims to evaluate post-transplant oucomes in patients aged over 70 years, traditionally viewed as an age limit for transplant. We retrospectively analyzed 584 LT recipients (36 aged ≥70, 548 aged <70). Viral cirrhosis was more frequent in the younger group (36.1% vs. 13.1%), while MASLD was more common in those over 70 (25% vs. 13.1%) (p = 0.013). Model for End-Stage Liver Disease (MELD) scores were lower in patients over 70 (13, IQR 9–17) compared to the younger group (15, IQR 10–23) (p = 0.032). Propensity score matching (3:1 ratio, without replacement) was performed based on MELD and cirrhosis etiology. After matching, no significant differences were found in postoperative outcomes, overall survival, or graft survival. Our findings demonstrate that carefully selected patients over 70 can achieve post-transplant outcomes comparable to younger patients. Advanced age alone should not be considered an absolute contraindication; instead, a comprehensive, multidimensional assessment is essential to identify suitable candidates.