AUTHOR=Süsal Caner , Döhler Bernd , Demir Erol , Ibrahim Walaa , Askar Medhat 

TITLE=Corrigendum: Hidden in Plain Sight: High Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality

JOURNAL=Transplant International

VOLUME=Volume 38 - 2025

YEAR=2025

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2025.15860

DOI=10.3389/ti.2025.15860

ISSN=1432-2277

ABSTRACT=Graphical AbstractHigh tacrolimus metabolism is linked to increased kidney transplant failure and infection-related mortality. The study analyzed 21,865 kidney transplants from 2000 to 2019, the largest to date. About 25.2% had a low concentration-dose-ratio (CDR), predicting poor outcomes with a hazard ratio up to 2.80 and a 63% increase in infection-related mortality. Higher risk groups include females, young individuals, and those with CYP3A5*1A. Strategies like diltiazem co-medication and steroid tapering may improve long-term outcomes in patients with low CDR. Conducted by Caner Süsal, published in Transplant International.