AUTHOR=Cillo Umberto , Furlanetto Alessandro , Lanari Jacopo , Nieddu Eleonora , Rosso Eugenia , D’Amico Francesco Enrico , Bassi Domenico , Gringeri Enrico 
  
TITLE=Present and future of liver transplantation for cholangiocellular carcinoma: moving toward personalized multiparametric transplantability patterns
  
JOURNAL=Transplant International
  
VOLUME=Volume 39 - 2026
  
YEAR=2026
  
URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2026.15786
  
DOI=10.3389/ti.2026.15786
  
ISSN=1432-2277
  
ABSTRACT=Liver transplantation for cholangiocarcinoma (CCA) shifted from a contraindication to a promising therapeutic option for selected patients. Advances in neoadjuvant therapy and refined selection criteria resulted in long-term outcomes comparable to other accepted oncologic indications, particularly in perihilar CCA managed with standardized protocols and in intrahepatic CCA with favorable tumor biology. The future challenge is to develop a multiparametric biological selection, blending clinical, functional, histopathologic, molecular, and radiologic parameters to identify candidates with indolent disease behavior, thus maximizing oncologic benefit while ensuring appropriate use of limited graft resources.